What
is Infantile Neuroaxonal Dystrophy (INAD)?
Synonyms
-
INAD
-
Seitelberger Disease
Disorder Subdivisions
-
Prenatal or Connatal Neuroaxonal Dystrophy
General Discussion
Infantile
neuroaxonal dystrophy (INAD) is an extremely rare, inherited
degenerative disorder of the nervous system characterized
by abnormalities of nerve endings (axons) within the brain
and spinal cord (central nervous system) and outside the
central nervous system (peripheral nerves). In most cases,
infants and children with INAD appear to develop normally
until approximately 14 to 18 months of age, when they
may begin to experience progressively increased difficulties
in walking. In other cases, symptoms may begin at approximately
six to eight months of age, at which time infants may
experience delays or an arrest in the acquisition of skills
requiring the coordination of mental and physical activities
(delayed psychomotor development).
The
symptoms and physical characteristics associated with
infantile neuraxonal dystrophy are the result of swelling
and degeneration of nerve endings (dystrophic axonal swellings
or "spheroids") within and without areas of
the brain and spinal cord (central nervous system). In
most cases, INAD is inherited as an autosomal recessive
genetic trait.
Resources
NBIA
Disorders Association
http://www.nbiadisorders.org
WebMD
http://children.webmd.com/infantile-neuroaxonal-dystrophy
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
Tel: (914)428-7100
Fax: (914)997-4763
Tel: (888)663-4637
Email: Askus@marchofdimes.com
Internet: http://www.marchofdimes.com
United Leukodystrophy Foundation
2304 Highland Drive
Sycamore, IL 60178
Tel: (815)895-3211
Fax: (815)895-2432
Tel: (800)728-5483
Email: office@ulf.org
Internet: http://www.ulf.org/
NIH/National Eye Institute
Building 31 Rm 6A32
31 Center Dr MSC 2510
Bethesda, MD 20892-2510
United States
Tel: 3014965248
Fax: 3014021065
Email: 2020@nei.nih.gov
Internet: http://www.nei.nih.gov/
National Institute of Neurological
Disorders and Stroke (NINDS)
31 Center Drive
8A07
Bethesda, MD 20892-2540
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
Email: braininfo@ninds.nih.gov
Internet: http://www.ninds.nih.gov/
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